• NLRP3 phosphorylation in its LRR domain criticallyregulates inflammasome assembly

T. Niu, C. De Rosny, S. Chautard, A. Rey, D. Patoli,M. Groslambert, C. Cosson, B. Lagrange, Z. Zhang, O. Visvikis, S. Hacot, M. Hologne, O. Walker, J. Wong, P. Wang, R. Ricci, T. Henry, L. Boyer, V. Petrilli and B. Py

Nat. Commun., 2021, 12(1), 5862

  • NMR reveals the interplay between SilE and SilB model peptides in the context of silver resistance

L. Babel, M-H. Nguyen, C. Mittelheisser, M. Martin, K. Fromm, O. Walker and M. Hologne

Chem. Commun., 2021, 57(70), 8726-8729


  • Accurate Prediction of Protein NMR Spin Relaxation by Means of Polarizable Force Fields. Application to Strongly Anisotropic Rotational Diffusion

M. Marcellini, M-H. Nguyen , M. Martin , M. Hologne and O. Walker

J. Phys. Chem. B, 2020, 124, 25, 5103–5112


  • Molecular recognition of ubiquitin and Lys63-linked diubiquitin by STAM2 UIM-SH3 dual domain: the effect of its linker length and flexibility

M-H. NGUYEN , M. MARTIN , H. Kim , F. Gabel , O. Walker and M. Hologne

Sci. Rep, 2019, 9, 14645

  • Regulation of measles virus gene expression by P protein coiled coil properties.

Bloyet, L-M.; Schramm, A.; Lazert, C.; Raynal, B.; Hologne, M.; Walker, O.; Longhi, S.; Gerlier, D.,

Sci. Adv, 2019, Vol. 5, no. 5, eaaw3702


  • Alpha-helical folding of SilE models upon Ag(His)(Met) motif formation.

V. Chabert, M. Hologne, O. Seneque, O. Walker, KM. Fromm

Chem. Commun, 2018, 54(74), 10419-10422

  • Ab-initio Prediction of NMR Spin-Relaxation Parameters from Molecular Dynamics Simulations

P-C. Chen, M. Hologne, O. Walker and J. Hennig

J. Chem. Theory. Comput., 2018, 14(2), 1009-1019


  • Structural basis for the inhibitory effects of ubistatins in the ubiquitin-proteasome pathway

M. A. Nakasone, T. A. Lewis, O. Walker, A. Thakur, W. Mansour, C. A. Castañeda, J. L. Goeckeler-Fried, F. Parlati, T-F Chou, O. Hayat, D. Zhang, C. M. Camara, S. M. Bonn, U. K. Nowicka, S. Krueger, M. H. Glickman, J. L. Brodsky, R. J. Deshaies, D. Fushman

Structure, 2017, 25(12), 1-29

  • Model peptide studies of Ag+ binding sites from the silver resistance protein SilE

V. Chabert, M. Hologne, O. Sénèque, A. Crochet, O. Walker, KM. Fromm

Chem. Commun, 2017, 53(45), 6105-6108

  • Computing the Rotational Diffusion of Biomolecules via Molecular Dynamics Simulation and Quaternion Orientations

P.C. Chen, M. Hologne, O. Walker

J. Phys. Chem B, 2017, 121(8), 1812-1823


  • NMR reveals the interplay between the AMSH SH3 binding motif, STAM2 and Lys63-linked diubiquitin

M. Hologne, F-X. Cantrelle, G. Riviere, F. Guillière, X. Trivelli, O. Walker

J. Mol. Biol, 2016, 428(22), 4544-4558

  • Francisella tularensis IglG Belongs to a Novel Family of PAAR-Like T6SS Proteins and Harbors a Unique N-terminal Extension Required for Virulence

M. Rigard, J.E. Bröms, A. Mosnier, M. Hologne, A. Martin, L. Lindgren, C. Punginelli, C. Lays, O. Walker, A. Charbit, P. Telouk, W.Conlan, L. Terradot, A. Sjöstedt, T. Henry

Plos Pathogens, 2016, 12(9)

  • Linkage via K27 bestows ubiquitin chains with unique properties among polyubiquitins

C. A. Castaneda, E. Dixon, O. Walker, A. Chaturvedi, M. A. Nakasone, J. E. Curtis, M. R. Reed, S. Krueger, T. A. Cropp, D. Fushman

Structure, 2016, 24(3), 423-436


  • DNA-damage-inducible 1 protein (Ddi1) contains an uncharacteristic ubiquitinlike domain that binds ubiquitin

U. Nowicka, D. Zhang, O. Walker, D. Krutauz, C.A. Castañeda, A. Chaturvedi, T.Y. Chen, N. Reis, M.H. Glickman and D. Fushman

Structure, 2015, 23(3), 542-557

  • Funnel Metadynamics and Solution NMR to Estimate Protein-Ligand Affinities

L. Troussicot, F. Guillière, V. Limongelli, O. Walker, J-M. Lancelin

J. Am. Chem. Soc, 2015, 137(3), 1273-1281


  • Versatile Roles of K63-Linked Ubiquitin Chains in Trafficking

Z. Erpapazoglou, O. Walker, R. Haguenauer-Tsapis

Cells, 2014, 3, 1027-1088


  • BcL-xL conformational changes upon fragment binding revealed by NMR

C. Aguirre, T. Ten Brink, O. Walker, F. Guillière, D. Davesne, I. Krimm

Plos One, 2013, 8(5)


  • Competitive binding of UBPY and ubiquitin to the STAM2 SH3 domain revealed by NMR

A. Lange, M-B. Ismail, G. Riviere, M. Hologne, D. Lacabanne, F. Guillière, J-M. Lancelin, I. Krimm, O. Walker

FEBS. Lett, 2012, 586 (19), 3379

  • Evidence for Cooperative and Domain-specific Binding of the Signal Transducing Adaptor Molecule 2 (STAM2) to Lys63-linked Diubiquitin

A. Lange, C. Castañeda, D. Hoeller, J-M. Lancelin, D. Fushman, O. Walker

J. Biol. Chem, 2012, 287(22), 18687


  • NMR reveals a different mode of binding of the Stam2 VHS domain to ubiquitin and diubiquitin

A. Lange, D. Hoeller, H. Wienk, O. Marcillat, J-M. Lancelin, O. Walker

Biochemistry., 2011, 50, 48-62


  • Exploring the linkage dependence of Polyubiquitin Conformations using molecular modeling

D. Fushman and O. Walker

J. Mol. Biol., 2010, 395, 803-814


  • NMR screening applied to the fragment-based generation of inhibitors of creatine kinase exploiting a new interaction

proximate to the ATP binding site

A. S. Bretonnet, A. Jochum, O. Walker, I. Krimm, P. Goekjian, O. Marcillat, J. M. Lancelin

J. Med. Chem., 2007, 50(8), 1865-75


  • Protein-protein interactions within peroxyredoxin systems

V. Noguera-Mazon, I. Krimm, O. Walker, JM. Lancelin

Photosynth. Res. 2006, 99, 277

  • Glutathionylation induces the dissociation of 1-Cys D-peroxiredoxin non-covalent homodimer

V. Noguera-Mazon, J. Lemoine, O. Walker, N. Rouhier, A. Salvador, J. P. Jacquot, J. M. Lancelin, I. Krimm.

J. Biol. Chem., 2006, 281, 31736-42


  • NMR reveals a novel glutaredoxin-glutaredoxin interaction interface

V. Noguera, O. Walker, N. Rouhier, JP. Jacquot, I. Krimm, Lancelin JM

J. Mol. Biol., 2005, 353, 629-641

  • Crystal structure and solution NMR dynamics of a D (type II) peroxiredoxin glutaredoxin and thioredoxin dependent: a new insight into the peroxiredoxin oligomerism.

A. Echalier, X. Trivelli, C. Corbier, N. Rouhier, O. Walker, J. P. Jacquot, A. Aubry, I. Krimm, J. M. Lancelin

Biochemistry, 2005, 44(6), 1755-1767


  • Characterization of the overall rotational diffusion of a protein from 15N relaxation measurements and hydrodynamic calculations

J. Black-Hall, O. Walker, D. Fushman

Methods. Mol. Biol., 2004, 278, 139-160

  • Determining domain orientation in macromolecules by using spin-relaxation and residual dipolar coupling measurements.

D. Fushman, R. Varadan, M. Assfalg, O. Walker

Prog. Nucl. Magn. Reson. Spectrosc., 2004, 44, 189-214

  • Efficient and accurate determination of the overall rotational diffusion tensor of a molecule from 15N relaxation data using computer program ROTDIF

O. Walker, R. Varadan , D. Fushman

J. Magn. Reson., 2004,168(2), 336-345


  • Heteronuclear Overhauser Experiments for symmetric molecules

O. Walker, P. Mutzenhardt, D. Canet

Magn. Res. Chem., 41(10), 2003, 776-781


  • Structural properties of polyubiquitin chains in solution

R. Varadan, O. Walker, C. Pickart, D. Fushman

J. Mol. Biol., 2002, 324, 637-647

  • Solvent dependence of rotational anisotropy and molecular geometry as probed by NMR cross-relaxation rates.

O. Walker, P. Mutzenhardt, J. P. Joly, D. Canet

Chem. Phys. Lett., 2002, 357, 103-107

  • Determination of the rotation-diffusion tensor orientation from NMR 13C-1H cross relaxation rates

O. Walker, P. Mutzenhardt, E. Haloui, J. C. Boubel, D. Canet

Mol. Phys., 2002, 100(17), 2755-2761

  • Determination of Carbon-13 chemical shielding tensor in the liquid state by combining NMR relaxation experiments

and quantum chemical calculations.

O. Walker, P. Mutzenhardt, P. Tekely, D. Canet

J. Am. Chem. Soc., 2002, 124, 865-873


  • Synthesis and spectral study of (2R,11R)-2,11-bis{[(2-methoxyethoxy)methoxy]methyl}-1,10-


J. P. Joly, O. Walker, P. Mutzenhardt

Magn. Res. Chem., 2001, 39, 212-214


  • Anisotropy of molecular reorientation and geometrical information as determined from short and long range

13C-1H spin cross relaxation rate

P. Mutzenhardt, O.Walker, D. Canet, E. Haloui, I. Furo

Mol. Phys., 1998, 94, 565-569